Alzheimer’s disease (AD) is currently recognized as an untreatable, progressive, degenerative and terminal disease that is globally afflicting an estimated 36 million people and this number is growing in an unabated and frightening manner. Advances in Alzheimer Research, provides researchers with an integrated approach to AD academic literature ranging from basic to advanced clinical research. The series highlights the latest information in order to unravel the origin, pathogenesis and prevention of AD. The purpose of this book series is, therefore, to capture and discuss both, improvements towards the diagnosis and potential treatment of AD by established and novel strategies. This first volume of the series provides an important mechanism to bring individuals having a variety of scientific interests and expertise under one roof to specifically focus on AD and related dementias. This volume presents articles on beta amyloid protein targets as well as research on secretase enzyme systems among other topics that deal with AD therapy.

Alzheimer’s disease (AD) is currently recognized as an untreatable, progressive, degenerative and terminal disease that is global – afflicting over 36 million people worldwide, with the number growing in an unabated and frightening manner. The goal of the series Advances in Alzheimer’s Research , with Volumes 1 and 2, is to provide an integrated approach to AD from basic and clinical research and to highlight the valuable information in order to unravel the origin, pathogenesis and prevention of AD. The aim of this book is to both capture and discuss improvements toward the diagnosis and potential treatment of AD by both established and novel strategies. This book series, including the Volume 2, provides an important mechanism to bring under the same roof a variety of scientific interests and expertise to specifically focus on AD and related dementias. The fullest attempt has been made to disseminate the most current knowledge on recent advances in potential therapy of AD.

Triple negative breast cancers (TNBC) are a biologically aggressive form of breast cancer and constitute approximately 10-15% of all breast cancer patients. Distant metastasis, lack of clinically targeted therapies and prognostic markers, makes the disease difficult to treat. Till now not much work has been carried out on this deadly disease. This book provides an overview of TNBC etiology, its treatment strategies and prognostic markers to identify the outcome of standard therapies. Signalling pathways namely cell proliferation, angiogenesis, invasion and metastasis, apoptosis, autophagy and others involved in complicating the disease have been described in the chapters to convey an understanding about the disease mechanisms. All the possible drugs either in pre-clinical or clinical stages have also been mentioned with data that depicts their efficiency in targeting altered genes. The book also introduces the reader to herbal medicine exhibiting high potency to target TNBC, their synthetic analogs used during chemotherapy and their ability to fight against chemoresistance. The concept of phytonanotechnology has also been discussed. The book helps create awareness among a broad range of readers about TNBC. It points to prioritizing the upgradation of health care facilities and re-designing future treatment strategies to provide maximum benefit to breast cancer patients.

Recent Trends and the Future of Antimicrobial Agents provides a significantly expanded overview of the topic with updated research in a broader context on the development of alternative approaches against microbial infections. This part consists of ten chapters. The first five chapters describe naturally derived antimicrobial compounds such as plant-based antimicrobials (PBAs), enzymes-based and antibody-based antibacterial therapeutic and secondary metabolites from plant endophytes. The book proceeds to provide details about antimicrobials derived from marine microorganisms (bacteria, fungi, actinomycetes, and cyanobacteria) is included to inform readers about effective medications against MDR strains. Specific chapters describe the drug development against protozoans, with one chapter focusing on Plasmodium. Chapter contributors have postulated novel approaches for antimalarial therapeutics. The book also includes an explanation of host target identification and drug discovery with the purpose of informing the reader about the implications in viral biology and how they could be exploited for treating viral diseases. The contents cater to the information needs of professionals and learners in academia, industry and health services who aim to learn the most significant experimental and practical approaches towards finding alternatives to existing antimicrobial therapies.

This book explores the different ways sleep medicine is practiced in the world by presenting information from multiple countries from all continents. The editors, all sleep medicine experts, dive into both clinical practice, and research keeping an eye on healthcare needs and disparities, before proposing solutions. The contributions also take into account the social, geographical and political situation of each country, along with demographic considerations such as income levels, adding a dimension of context to the contents. The book is meant to be a reference for sleep medicine practitioners who encounter diverse patients in their daily practice. It also serves as a good resource for anyone interested in the state of global health studies.

Despite an increase in life expectancy over the past 20 years, the number of novel, multi-drug resistant microorganisms has also risen dramatically. To reduce the risk of reemerging infections, and limit the spread of multidrug resistant microorganisms, it is urgently necessary to develop safe and effective therapeutic countermeasures. New antimicrobial chemicals are mostly produced with the help of microorganisms, and the bulk of medications now on the market are of this type. The use of high therapeutic screening and recent developments in analytical instrumentation has allowed the researchers to identify novel antimicrobial compounds from bacteria, fungi, plants, mushrooms, algae, and other sources more quickly. The second volume of Frontiers in Antimicrobial Agents highlights the ongoing requirement for researching and creating novel antimicrobial medications. Current Trends in the Identification and Development of Antimicrobial Agents aims to bring together the expertise of notable academics to examine all facets of antimicrobial research while keeping recent advancements in perspective. Antibiotic discovery, sources of novel antimicrobial chemicals, developing and reemerging microbial infections, various elements of drug resistance, and the need for antimicrobial medications in the future are all covered in this book. It is a timely reference for anyone involved in the discovery and development of new drugs, including microbiologists, biotechnologists, pharmacologists, doctors, and researchers.

Advances in the treatment of neurodegenerative diseases (NDs) are nominal. Currently available therapies are merely symptomatic treatments that cannot prevent the development of the disease. Several herbs have been found very useful for managing neurological diseases. There are immense possibilities to discover a more successful line of ND treatment. Phytochemicals from medicinal plants may play a vital role in maintaining the chemical balance of the brain by affecting the capacity of receptors for the major inhibitory neurotransmitters. A few plants have already gained popularity for the potential treatment of NDs. This volume highlights the therapeutic role of medicinal plants and their scientific validation for improving neuronal health. It presents 15 chapters that cover the herbal treatment of NDs, including Parkinson’s disease and Alzheimer’s disease. The contents cover a range of pharmaceutical agents like sirtuins, berberine, rosmarinic acid and resveratrol. The book serves as a reference for pharmacology and herbal medicine scholars as well as healthcare workers interested in information about alternative and complementary therapies for neurological disorders.

Menopause is a significant milestone in a woman's life, marking the end of fertility and the start of a new phase. However, it can also bring many physical and emotional symptoms, such as hot flashes, mood changes, and a higher risk of osteoporosis and heart disease. Because of these issues, dealing with menopause can be a challenge. From Taboo to Wellness: The Facts behind Menopause is an informative guide to menopause. It provides clarity and accessibility for anyone interested in understanding the topic, and wants to deconstruct any myths that surround it with facts. From symptoms to treatments, this book covers everything you need to know about menopause in an engaging and easy-to-understand way. Written with the general reader in mind, this book explores the science behind menopause, as well as the male andropause and how it differs from the female experience. With insights into Hormone Replacement Therapy (HRT) and future treatments using stem cells, it gives a comprehensive understanding of the options for managing menopause. But that's not all - the book also delves into the fascinating world of menopause in the animal kingdom, offering a unique perspective on how different species experience hormonal changes caused by this life-changing event.

Illustrated Pediatric Dentistry is intended to be a text book for enhancing the knowledge and understanding of paediatric dentistry amongst undergraduate and postgraduate students. This textbook is updated with the latest information on techniques employed in paediatric dentistry. Chapters in this part cover primary paediatric dentistry, its clinical aspects, preventive dentistry, and information about the latest trends prevalent in this specialty field of dentistry. The text will equip readers with the knowledge suited to the changing environment of this vital domain. The editor of this textbook has over forty-four years of teaching experience in paediatric dentistry and is able to successfully impart a broad perspective of the subject through the book’s contents. This textbook is the amalgamation of the experience and knowledge of various subject experts that command a high international reputation. Part 2 covers orofacial swelling, pediatric space management, interceptive orthodontics and myofunctional therapy, gingival and periodontal diseases, oral hygiene, minimum intervention dentistry (MID), molar incisor hypoplasia (MIH), restorative dentistry, and oral examination and diagnostic aids used in pediatric dentistry. Key Features: - The 15, structured chapters present the latest trends in paediatric dentistry - The book content is illustrated with quality clinical images, - Chapters cover contemporary concepts of problems experienced when treating multiple dental disorders in young patients - Contributions from subject experts present distinct clinical expertise and a unique style of imparting important current knowledge to budding professionals - The book includes modern and current state-of-the-art techniques used in the clinic - Topic outlines throughout the book will greatly help readers to quickly locate and review the content. Contents of the book are very well structured and presented in a lucid manner, making it easy to understand.

Drug repurposing is a cost-effective method of discovering new treatments for diseases than traditional drug development methods. It involves virtual screening of chemical candidates with the aid of computational methods like molecular docking. Drug Repurposing against SARS-CoV2 focuses on current trends in drug repurposing against the novel coronavirus strains. The book aims to give readers an overview of drug repurposing against COVID-19 and various techniques involved in the process. The book consolidates available information on the pathophysiology, drug targets, and drug repurposing against COVID-19 into a single, convenient resource. Key features -An up-to-date compilation of the evidence that supports the drug repurposing for COVID-19. -How to use repurposing of available drugs for disease therapy. -Provides an improved understanding of pathophysiology and SARS-CoV2 viral entry pathways. - Provides references for further reading