Advances in technology have enabled medicinal chemists to discover and formulate several highly specific, biocompatible, and non-toxic therapeutic agents for clinical applications. Nanotechnology has achieved significant progress in the last few decades and is crucial in every field of science and technology. Nanotechnology-based pharmaceuticals offer multifaceted and alternative methodologies in comparison to the limitations of many conventional clinical therapies. Expertise in designing and developing nanoformulations has helped in targeted drug delivery. Recently, the use of innovative therapeutic agents, particularly in nanomedicine, has accounted for a significant portion of the global pharmaceutical market and is predicted to continue to grow rapidly in the near future. Nanotherapeutic Strategies and New Pharmaceuticals is an accessible multi-part reference which informs the reader about several new techniques based on nanotechnology. The chapters explain relevant topics in detail. The book is designed to encourage and help undergraduate, graduate and post-graduate students in the field of nanotherapeutics, pharmaceuticals and bio-organic chemistry through the use of didactic language and simple illustrations. Part 2 of this book covers the potential of nanotherapeutics and natural therapies for treating neurological diseases, targeting ion channels, signal transduction therapy, gene therapy of single gene mutation diseases and for nanoformulations for special purposes such as wound healing and stimuli-responsive drug delivery. The book also features a chapter that summarizes the types of nanoparticles tailored for specific molecular targets that mediate different diseases. The book set serves as a textbook for students in pharmacology and medical biochemistry, as well as a quick reference for researchers on bio-organic chemistry, as well as general readers interested in nanomedicine.

The Microfabrication technology has stimulated a plurality of lab-on-a-chip research for biomedical researchers and health care practitioners to manipulate and analyze complex biological fluids at the nano and microliter scale. Specifically, various miniaturized diagnostic devices have been developed for blood sample detection, which can increase diagnostic capacity significantly by enabling rapid, point-of-care chemical analysis. Recently, more and more researchers are paying attention to on-chip whole blood sample pretreatment, which is the focus of this eBook, aiming to form real Micro Total Analysis Systems (uTAS) for whole blood analysis by integrating blood sample pre-treatment and detection together. The eBook consists of six chapters. Chapter 1 gives a brief introduction on the background of whole blood and the concept of µTAS, followed by a summary of specific microfluidic chips for whole blood pretreatment. Chapter 2 firstly reviews microfluidic chips for plasma isolation from whole blood samples with various methodologies (i.e., microfiltration, microcentrifugation, ultrasound, Zweifach–Fung effect and capillary effect). Then two examples using the plasma skimming effect and crossflow filtration respectively are discussed in detail. Chapter 3 firstly reviews microfluidic devices for blood cell filtrating, sorting and collection. Sorting methods such as size filtration, optical and magnetic manipulation, affinity separation, dielectrophoretic manipulation are covered and compared. Then a case study using crossflow filtration is analyzed in detail. Chapter 4 firstly reviews reported microfluidic devices for blood cell lysis in which mechanical lysis, sonication lysis, thermal lysis, electrical lysis, chemical lysis and optical lysis are covered. And then a cell lysis microchip using chemical agents for cell lysis is chosen as an example for further concept demonstration. Chapter 5 firstly reviews microfluidic devices for DNA extraction and purification by comparing reported methods of solid phase extraction, solid phase reversible immobilization and liquid/liquid extraction. And then two microchips with different solid phase matrixes are used for demonstration of chip based DNA extraction. Chapter 6 firstly reviews current integrated microfluidic platforms for blood pretreatment, followed by a case study. Both fundamental analysis and specific applications are presented in this eBook, which is written for researchers, engineers, and advanced students who have research interest in whole blood pretreatment and miniaturized techniques. We would like to express our appreciation to Bentham Science Publishers and their team members.

Over the last few decades, numerous nanoparticle platforms have been studied for their use in therapeutic applications. This book deals with the description of the construction of technical systems that combines different functionalities which bring liposomes, polymer-drug conjugates, polymer-protein conjugates, dendrimers, polymeric micelles, polymerosomes and other nanoparticles into the realm of nanotechnology proper, as opposed to traditional pharmacology or supramolecular chemistry. The volume additionally covers topics such as passive and active targeting, the strategies used for drug targeting, and the synthesis and characterization of polymeric nanoparticle platforms. Targeted polymeric nanomedicines have shown exciting results in preclinical studies, demonstrating their potential as therapeutic carriers. Therefore, the development of polymeric nanomedicines as therapeutic agents has generated great enthusiasm both in academia and industry. The book is systematically divided into chapters devoted to a class of polymeric nanomedicines. Each chapter also describes relevant aspects relating to drug design and targeting of polymeric nanomedicines wherever possible. In addition, a series of chapters concerning the contribution of polymeric nanomedicines in the treatment of several categories of diseases including cancer, inflammatory, renal, immunological diseases, and brain disorders is also presented. Key features of this book include: - A comprehensive and cutting-edge overview of polymeric nanomedicines available in a single dedicated volume - Discussions on advances in drug delivery systems for a variety of diseases - more than 2000 references, tables, equations, and drawings Readers, whether beginners or experts, will find in this book, contemporary and relevant information regarding the synthesis, evaluation and applications of polymeric nanomedicines. Supplemented with extensive bibliographic references, tables and figures, this book is an essential and incomparable reference for medicinal chemists, biologists, and medical (oncologic) researchers, as well as for scientists, undergraduate and graduate students in the field of medical bioengineering and polymer nanoscience.

Toxic Effects of Nanomaterials provides an authoritative work of international experts in the field of nanotoxicology spanning 8 chapters. A key feature of the e-book is a broad coverage of phytotoxicity of nanoparticles, which is largely neglected in many texts. The first couple of chapters of this book deal with the toxicity of nanoparticles in plants. This is followed by a discussion on the toxicities of iron oxide, titanium oxide and silicon oxide nanoparticles. Next, the volume provides a comprehensive review of methodologies used in nanotoxicology surveys. The concluding chapters highlight the risks associated with the use of nanoparticles and the environmental impact of nanomaterials. Such a broad coverage of nanotoxicology renders this book highly beneficial to the scientists from multidisciplinary areas including nanotechnologists, toxicologists, pharmacologists, environmental chemists and biomedical scientists. This book would equally be useful for the individuals advocating for sustainable use of nanotechnology.

The convergence of nanotechnology with agriculture has transformed farming, while also impacting medicine, biotechnology and environmental science. Plant extracts isolated using new technologies have been used to successfully create new medicines for specific diseases. This book focuses on the eco-friendly synthesis of plant extracts. It provides information about multifunctional nanoparticles, and their versatile applications, including agriculture, food safety, and environmental remediation. The book aims to bridge the gap between nanotechnology and public perception, addressing concerns related to health and environmental impact. Themes within the book span across green synthesis techniques for noble metal nanoparticles, the crucial role of analytical methods in characterizing these "green nanomaterials," and the comprehensive examination of how nanoparticles interact with the human body. Furthermore, the intricate relationships between proteins and nanoparticles is highlighted to explain the physicochemical effects and toxicity of nanomaterials. Readers will learn about sustainable and environmentally friendly approaches for synthesizing nanoparticles, while getting a glimpse of the promising future of nanotechnology in agriculture and beyond.