Bioencapsulation (or microencapsulation) of cells and their implantation into a body of immunoprotected cells allows researchers to revive a missing or defective function in the cells. Microencapsulated cells have reached the clinic where they have been shown to be safe and efficacious in numerous clinical trials. Cell types that have been encapsulated for therapeutic purposes include hybridomas, islet cells, "platform" cell lines e.g. HEK293 and CHO cells as well as an increasing focus on the encapsulation of stem cells. This e-book explains the different methods used for achieving cell bioencapsulation based on different polymers e.g. alginate, cellulose sulphate and agarose. Other chapters in this book subsequently describe the use of cell encapsulation in cancer therapy to improve on existing chemotherapies by reducing doses and thus side effects while increasing efficacy for long term in vivo production of (i) tumoricidal or virus neutralising antibodies, (ii) insulin to achieve a self regulating treatment for diabetes and (iii) neuron nurturing factors to treat CNS diseases such as epilepsy, disorders like Parkinson's disease, Alzheimer, Amyotrophic lateral sclerosis, Huntington's disease and pathologies caused by trauma and/or ischemic processes. The book also includes a chapter reviewing the genetic engineering of cells to allow controlled production of biotherapeutics from encapsulated cells. This is a unique and timely book which brings together contributions from some of the leading researchers in the field of cell encapsulation. Interested readers are provided an overview of the exciting developments and clinical experiences of researchers with cell bioencapsulation.

Increasing public health concern about healthy lifestyles has sparked a greater demand among consumers for healthy foods. Natural ingredients and environmental friendly food production and processing chains are more aligned to meeting the demand for healthy food. There is a wide array of food additives and chemicals that have nutritional value. The biotechnological food production processes, therefore, vary for different types of food chemicals and ingredients accordingly. Biotechnological Production of Natural Ingredients for Food Industry explains the main aspects of the production of food ingredients from biotechnological sources. The book features 12 chapters which cover the processes for producing and adding a broad variety of food additives and natural products, such as sweeteners, amino acids, nucleotides, organic acids, vitamins, nutraceuticals, aromatic (pleasant smelling) compounds, colorants, edible oils, hydrocolloids, antimicrobial compounds, biosurfactants and food enzymes. Biotechnological Production of Natural Ingredients for Food Industry is a definitive reference for students, scientists, researchers and professionals seeking to understand the biotechnology of food additives and functional food products, particularly those involved in courses or activities in the fields of food science and technology, food chemistry, food biotechnology, food engineering, bioprocess engineering, biotechnology, applied microbiology and nutrition.

This eBook presents a comprehensive review on the chemical composition of natural products derived from honeybee farming. These products include honey, pollen and propolis. Each chapter details specific products and the contents are complemented with an explanation of distinct analytical techniques for studying these products. Readers will also find a summary of current information about biological properties and applications of honey, pollen and propolis, which contribute to added value to these bee and plant-derived products. The eBook is a handy reference for students, researchers and laymen studying the biochemical aspects of apiculture.

Carbohydrates (monosaccharides, oligosaccharides and polysaccharides) exist naturally in free from and as components of other macromolecules (nucleic acids, proteins and lipids). Glycotherapy refers to this use of carbohydrates or glycoengineered macromolecules in fighting life-threatening diseases. Although glycotherapy is a relatively new and limited field of pharmacology, significant progress has been made in recent years in academia and the pharmaceutical industry facilitated by advances in enzymology and recombinant DNA technologies. Consequently, carbohydrate containing biologics are now used in therapeutic regimens. This volume provides a summary of the progress made in developing therapeutic solutions using glycoengineering techniques. Topics covered in this volume include the development of vaccines and antibodies against tumor-associated carbohydrate antigens for cancer treatment, the use of glycan for viral inhibition, glycoPEGylation, hyaluronic acid conjugation, and protein modification and conjugation for increasing therapeutic index using recombinant and chemoenzymatic approaches. The volume is essential reading for biochemists, pharmacologists and R&D professionals interested in glycotherapy.

Global plastic production is estimated to be over 300Mt annually. Most conventional plastics are predominantly produced from fossil fuels and are highly resistant to biodegradation, and only a small share of about 20% of spent plastics is believed to be recycled, which is a cause for environmental concern. Biodegradable plastics would solve this concern as they are a sustainable alternative, yet these do not even cover 5% of the global plastic market. Microbial polyhydroxyalkanoates (PHAs) are a versatile group of polyesters produced by nature as prokaryotic storage materials. PHAs can be produced through sustainable bioprocess engineering and have displayed remarkable flexibility in their physical and chemical properties. PHAs are the subject of several scientific papers and numerous PHA patents have also been filed, generating significant interest in the plastic production industry. To develop overall sustainable and efficient production processes, all bioprocess steps need to be thoroughly understood and accounted for. These processes start with the selection of suitable inexpensive raw materials (microbes and enzymes), optimizing the process engineering and process regime, and conclude with the enhancement of product recovery in terms of time, energy, and material input. Microbial Biopolyester Production, Performance and Processing: Microbiology, Feedstocks, and Metabolism encompasses eight chapters that cover aspects of the microbiology and biotechnology of producing biodegradable plastics. The contents focus on the selection of powerful archaeal and eubacterial production strains, genetic engineering as a tool for optimized PHA production and inexpensive carbon sources for microbial cultures. The volume is a useful resource for bioprocess engineers, microbiologists, biotechnologists and chemical engineers interested in the basics of biodegradable plastic production. Recent Advances in Biotechnology is a book series comprising of peer-reviewed reference works and monographs that compile the latest developments in the field of biotechnology. Each volume has a thematic focus and features topical reviews written by experts. The series will highlight multidisciplinary perspectives to interested readers (biotechnologists, microbiologists, bioprocess engineers, agronomists, medical professionals, sustainability researchers etc.)

Global plastic production is estimated to be over 300Mt annually. Most conventional plastics are predominantly produced from fossil fuels and are highly resistant to biodegradation, and only a small share of about 20% of spent plastics is believed to be recycled, which is a cause for environmental concern. Biodegradable plastics would solve this concern as they are a sustainable alternative, yet these do not even cover 5% of the global plastic market. Microbial polyhydroxyalkanoates (PHAs) are a versatile group of polyesters produced by nature as prokaryotic storage materials. PHAs can be produced through sustainable bioprocess engineering and have displayed remarkable flexibility in their physical and chemical properties. PHAs are the subject of several scientific papers and numerous PHA patents have also been filed, generating significant interest in the plastic production industry. To develop overall sustainable and efficient production processes, all bioprocess steps need to be thoroughly understood and accounted for. These processes start with the selection of suitable inexpensive raw materials (microbes and enzymes), optimizing the process engineering and process regime, and conclude with the enhancement of product recovery in terms of time, energy, and material input. Microbial Biopolyester Production, Performance and Processing: Bioengineering, Characterization, and Sustainability is a compilation of eight chapters covering bacterial polyesters, green plastics and PHAs from various angles. The contents of this volume focus on sustainable practices focus on the sustainability of processes that involve the synthesis and recycling of these meterials. The volume is a useful resource for bioprocess engineers, microbiologists, biotechnologists and chemical engineers interested in the basics of biodegradable plastic production.

Progress in Food Biotechnology covers recent advances in the food processing sector. Readers will gain an academic and industrial perspective on how biotechnology improves food product quality, yield, and process efficiency. Novel opportunities for utilizing value-added products in the food industry, such as microbial cultures, enzymes, flavour compounds, and other food ingredients are also explained. Chapters in the volume cover topics related to (1) food bioactive peptides and functional properties of proteins, (2) classification, biosynthesis, and application of bacterial exopolysaccharides, (3) enzymatic modification of phospholipids, and related applications, (4) microbial culture research and application in food fermentation, (5) probiotics, prebiotics, and synbiotics, (6) biotechnological production of food additives, (7) phenolic-based nanoparticles and relevant applications, (8) enzyme discovery approaches and industrial dairy enzyme applications, (9) bioconversion of major industrial and agro-industrial by-products into various bio-products as examples of a bio-based economy, and (10) plant epigenetics and future prospects of epigenetics to improve crop quality. Information is presented in a simple language supported by graphs, tables, numbers, market trends, and accounts of successful product launches. This volume is a handy resource for a broad range of industrial researchers, students, and biotech professionals from both academia and industry who are involved in the multidisciplinary fields of food biotechnology and food chemistry.

More than 4 decades have passed since the birth of the first in vitro fertilized baby in 1978. The use of assisted reproductive technology (ART) to overcome infertility has increased steadily with the simultaneous increase in the number of fertility centers in every part of the world. Access to infertility clinics is playing an important role in the treatment of different forms of infertility (like tubal disease, ovarian aging, or ovarian dysfunction). This book captures the state of current and recent advances in assisted reproduction technology in humans and livestock in an easy and comprehensive way for non-experts and learners. 10 chapters cover the biology of reproduction, and male ART methods (sperm retrieval and freezing) and female ART methods (oocyte activation, and cryopreservation), and finally embryo ARTs (assisted hatching and cloning techniques) with simple definitions and explanations. Tips to overcome problems are also presented where appropriate along with references for further reading. This book is a simple primer for students who are involved in courses in embryology or reproductive technologies as part of programs in biology, biotechnology, medicine, and physiology.

Biofuels are currently used as a viable alternative energy source in several countries. Plant-Based Genetic Tools for Biofuels Production explains biotechnological techniques and concepts that are applied to increase biofuel yield from plants and algae. Chapters of the book cover a variety of topics: the basic research techniques (cell suspension, embryogenesis, protoplast fusion), plant genetics (plant DNA mutations, new plant breeding techniques, viral genetic vectors for heterologous gene expression, sub cellular proteomes), genomic resources and bioinformatics tools, plant species with bioenergy and biofuel potential, factors influencing biomass yield, advances in cultivation technologies, fermentation of different substrates for ethanol production, and microalgae biomass technologies. Readers will gain a thorough understanding of modern biofuel production. Plant-Based Genetic Tools for Biofuels Production is a suitable reference for students in biotechnology and bioinformatics programs as well as researchers interested in information about the basics of biofuel production.

Heavy metal pollution represents a global challenge to both public health and environmental sustainability. Any means to reduce heavy metal pollution in the environment is of considerable economic significance. The use of green plants to clean up heavy metal pollution is an environmentally friendly as well as a low-cost approach to the problem. This plant-based biotechnology is commonly known as ‘phytoremediation’. Presently, there is limited application of this technology because useful plants with enhanced heavy metal resistance/tolerance are still needed to assist remediation of environments polluted with heavy metals. A key to improved phytoremediation of heavy metal pollution lies in research seeking for a better understanding of the mechanism(s) of heavy metal resistance/tolerance in plants. This E-book presents a unique treatment of the topics that have never been comprehensively brought together before in a single advanced reference. The volume explores aspects of plant biology that are critical for employing phytoremedation techniques to combat heavy metal contamination such as the specific plant biology, seed biology, plant tissue culture and enzymology. This E-book will be a useful reference to plant biologists, biotechnologists and environmental engineers seeking information about phytoremediation of heavy metals from the environment.